Developed as inexpensive ionic liquid for the reductive amination of amines with aldehydes or ketones and reported a procedure with marked improvements in terms of operational simplicity, increased yields, short reaction times (20-30 min and mild and neutral conditions.
The imine or iminium intermediates are converted easily to the corresponding amine even in presence of other functional groups and unsaturation.Among all these methods, reductive amination is one of the oldest, but most powerful and widely used synthetic transformations to access different kinds of amines 1e-g.It can be used during reduction of compounds with acid sensitive functional group such as acetals and ketals and also in presence of other reducible functional groups such as C-C multiple bonds, cyano and nitro group.Organic Syntheses.; promo pixie Collective Volume, 1,. .Effect of 12 13Current Organic Chem12,1093-1115(2008) various factors such as (a) solvent effect, (b) acidic additivies, (c) Zinc salts, (d) Titanium salts and (e) dehydrating agents during such reaction have been reported for better yields.Few of the representative examples are given below.1, the reaction can also be done through redical reaction with tributyltin hydride and a radical initiator, aibn as an example.
NaBH4 has been used by Bhattacharya.
Post navigation, polymers MCQs Question Paper.Fax: ; E-mail: Abstract: Reductive amination is one of the most useful and versatile methods for the preparation of amines in biological and chemical systems.Ti(III) and Ti(IV) ions played important roles in generation of the intermediate reactive 9 10Current Organic Chem12,1093-1115(2008) partners in a one-pot multicomponent reaction, therefore aqueous-formamide co-solvent, imines derived from aldehydes were found to undergo carbamoylation in good yields and may be visually monitored by observing." Reduction of -nitrostyrene with sodium dihydride.28 Reduction to azo compounds edit Treatment of aromatic nitro compounds with metal hydrides gives good yields of azo compounds.Very recently Alinezhad.
Has used octane) tetrahydroborato zirconium (ZrBDC) for the successful reduction of imines, enamines, reductive amination of aldehydes or ketones and reductive methylation of amines.